Case of Mallory-Weiss Syndrome in a Case of Small Cell Lung Cancer of the Lung Treated by Chemotherapy

Abstract

Nausea and vomiting are the most common side effect associated with the use of cisplatinum. We experienced one fatal case of hematemesis caused by Mallory-Weiss syndrome following cisplatinum chemotherapy. Autopsy findings revealed four rents in the gastric mucosa and massive coagula in the stomach. No abnormal findings in other organs could be observed.
Mallory-Weiss syndrome caused by chemotherapeutic agents is unusual and only nine cases have been reported, but it may occur more often in the near future with the widespread use of cisplatinum. Special attention should be paid during the administration of anticancer agents, especially cisplatinum.