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Volume 30, Issue 3
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[in Japanese]1990 Volume 30 Issue 3 Pages 309-311
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (228K) -
Haruhiko Nakamura, Ryuta Amemiya, Masayuki Niitsuma, Eisuke Takahashi, ...1990 Volume 30 Issue 3 Pages 313-318
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThirteen cases of adenoid cystic carcinoma of the tracheobronchial tree were studied clinically. In all cases, tumors developed in airways which were larger than lobar bronchi and no abnormality could be detected in 85% of the cases by plain chest X-ray films. Complete resection of the tumor was difficult, because the tumor often extended beyond the range of mucosal invasion evaluated before operation. Radiotherapy was performed in 9 cases and complete regression of the tumor was observed in 2 cases. Local chemotherapy with bronchial arterial infusion was also effective in 2 cases. Endoscopic Nd-YAG laser treatment was useful to widen the bronchial lumen. The 5-year survival rate was 44% overall. Multidisciplinary treatment is essential to prolong survival.View full abstractDownload PDF (5869K) -
Ryoich Kamimura, Tsutomu Takashima, Ken Kobayashi, Koji Nobata, Yoh Wa ...1990 Volume 30 Issue 3 Pages 319-326
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPostprocessing of image data is one of the unique capabilities of digital radiography that may improve diagnostic performance. Computed radiography (CR) using imaging plates is performed with a dedicated digital radiographic unit. Dual-energy subtraction can also be performed with the system. We studied the impact of digital chest imaging (CR) on the detection of lung cancers measuring 3cm or less in diameter in a comparison with conventional chest radiograms.
Visibility of pulmonary nodules on the chest radiography was evaluated by 2 radiologists in 52 pairs of CR and conventional radiography. The plain CR image was superior to conventional radiography especially for observation of nodules located in areas behind the heart and for nodules with distinct margins.
Dual-energy subtraction improved the detection of nodules in 11 cases (21%). In 2 nodules with ill-defined margins, however, the CR image was inferior to conventional radiography.View full abstractDownload PDF (9902K) -
Takashi Nakano, Hiroshi Fujioka, Juichiroh Maeda, Kei Yamaguchi, Noria ...1990 Volume 30 Issue 3 Pages 327-332
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSPleural fluid CEA levels were determined in 11 patients with malignant pleural mesothelioma, 65 bronchogenic carcinomas (adenocarcinoma 34, small cell carcinoma 18, squamous cell carcinoma 8, large cell carcinoma5), 13 metastatic pleural malignancies, 18 tuberculous pleurisy, and 21 other benign pleurisy, to evaluate the usefulness of pleural fluid CEA in distinguishing mesothelioma from bronchogenic carcinoma with pleural effusion. The mean CEA levels of each cell type of bronchogenic carcinoma and metastatic pleural malignancies were significantly higher than that in mesotheliomas. There was no significant difference in the pleural fluid CEA level between mesothelioma and tuberculous and other benign pleurisy. No case of malignant mesothelioma had levels of CEA in pleural fluid above the cut-off value of 5.0 ngjml, whereas 82.4% of adenocarcinoma, 28.6% of small cell carcinoma, 62.5% of squamous cell carcinoma, 83.3% of large cell carcinoma, and 43.8% of metastatic pleural malignancies were above the cut-off value. Serum CEA levels were not elevated and tissue CEA stainings were negative in all patients with mesothelioma. These results suggest that determination of CEA in pleural fluid and serum is helpful in distinguishing mesothelioma from bronchogenic carcinoma with pleural effusion.View full abstractDownload PDF (646K) -
Motoyasu Sagawa, Yasuki Saito, Satomi Takahashi, Katsuo Usuda, Keiji K ...1990 Volume 30 Issue 3 Pages 333-339
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe suitability and problems concerning current TNM classification of lung cancers were examined by analyzing the prognostic factors of cases of resected primary lung cancer. As a result, we confirmed the adequacy of dividing “previous T3” cases into two groups according to invaded organs and classifying cases with pleural effusion into two groups according to the existence of malignant cells in the pleural effusion. The problems which should be examined henceforth are classification of T4 cases which have a comparatively favorable prognosis (e.g., cases showing slight invasion in the left atrium and cases of carinal invasion), the way of standardizing methods used to detect intrapulmonary lymph nodes and accumulation of the results, and the necessity of subdividing N2 cases, etcetera.View full abstractDownload PDF (737K) -
Yoshinobu Ohsaki, Sakae Ishida, Toshiaki Fujikane, Jun-ichi Kawabe, Hi ...1990 Volume 30 Issue 3 Pages 341-349
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIt has been demonstrated that caffeine enhances the cytocidal effect of certain anticancer agents. The inhibition of DNA repair by caffeine has been considered to be one mechanism that enhances the cytocidal effect of such agents. The present study was conducted to clarify whether caffeine increases the effect of cisplatin (CDDP) on human lung adenocarcinoma cell line (PC9). CDDP concentrations used in this study were 1.0, 2.0μg/ml. After one hour treatment with CDDP, cells were washed twice with PBS and incubated in RPMI1640/10%FBS (CAF (-)) or in RPMI1640/10%FBS supplemented with 2mM caffeine (CAF (+)). Cell viability was examined by means of cell growth curves and clonogenic assay. Cell cycle analysis was performed by the two color analysis with propidium iodide (PI) and fluorescein isothiocyanate (FITC) stain using a flow cytometer (FCM). The uptakes of 3H-thymidine and 14C-leucine were measured by means of the liquid scintillation method. The results are as follows. Caffeine enhanced the cytocidal effect of CDDP at 1.0μg/ml synergisticaly. Caffeine decreased the G2M accumulation 24 hours after the CDDP exposure. Caffeine diminished fluorescence of FITC 48 hours after the CDDP exposure. The decrease of FITC fluorescence by caffeine was also observed in control. Caffeine decreased the uptake of 14C-leucine even in the control group which was not exposed to CDDP. From this data, we concluded that caffeine inhibits the protein synthesis in human lung cancer cells at a concentration which doesnot inhibit the growth of cancer cells significantly. Derangement of the protein synthesis might be the mode of caffeine-CDDP combination effect and it might give a hint as to the DNA repairing process.View full abstractDownload PDF (817K) -
Hiroshi Miyamoto, Hiroshi Isobe, Hitoshi Haneda, Toru Shimizu, Masao H ...1990 Volume 30 Issue 3 Pages 351-357
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDifferences between the nuclear DNA content of 23 central and 25 peripheral squamous cell carcinomas of the lung were examined by means of flow cytometry. The central tumors had an 83% rate of abnormal nuclear DNA content (DNA aneuploidy) and a DNA index of 1.65±0.40 (±SD). The peripheral tumors had DNA aneuploidy in 40% of cases and a DNA index of 1.29 ± 0.37. Peripheral tumors had significantly lower DNA aneuploidy (p <0.01) and DNA indices (p <0.01) than did central tumors. Patients with either peripheral or diploid tumors had significantly longer survival times (5-year survival of 60%) than did those with central or aneuploid tumors (23%, p<0.01). Smokers comprised 87.5% of the total (42 cases), 97.6% of the men (41cases), and 16.7% of the women (1 case). All six women is the study (five nonsmokers) had peripheral and diploid tumors. These results show that nuclear DNA content is useful for examining differences in pathogenesis and/or malignancy between central and peripheral squamous cell carcinomas of the lung.View full abstractDownload PDF (765K) -
Masayuki Kawasaki, Nobuyuki Hara, Yukito Ichinose, Akira Motohiro, Tom ...1990 Volume 30 Issue 3 Pages 359-364
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSBone metastases were reviewed among 1, 180 patients with lung cancer who were treated at the National Kyushu Cancer Center. The metastases were detected in 185 patients (15.7%) on initial staging. According to the histologic type, the metastatic rate in patients with squamous cell carcinoma was low (7.1%) as compared to that in patients with adenocarcinoma (19.9%) and small cell carcinoma (19.5%). Multiple bone metastases were seen more frequently in patients with adenocarcinoma than patients with other cell types. Median survival periods of patients who had bone metastases and other stage IV patients were 5.5 and 7.5 months, respectively. This difference on median survival time was statistically significant (p <0.02), implying that bone metastases is a poor prognostic factor. Radiotherapy was used in order to reduce pain, and 67.7% achieved partial or complete pain relief.View full abstractDownload PDF (594K) -
Masami Sato, Yasuki Saito, Noriyoshi Nagamoto, Katuo Usuda, Satomi Tak ...1990 Volume 30 Issue 3 Pages 365-373
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe question of whether the frequency of multiple primary squamous cell carcinoma of the lung in male heavy smokers varies with roentgenographical visibility was studied. One hundred and eight cases of roentgenographically visible lung cancer considered tohave absolutely treated by curative operation (P0 or p1, n0, m0, D0, E0, PM0 by histological examination after resection), and 124 cases of roentgenographically occult lung cancer, including those not subjected to resection, were included in the study. Selective brushings for all bronchi were performed in cases of roentgenographically occult lung cancer for full detection of multiple primary tumor since September 1986.
Multiple primary lung cancer was detected in 6 8cases (5.5-7.4%) of roentgenographically visible cancer and in 15 cases (12.1%) of roentgenographically occult cancer. The frequencies of multiple primary lung cancer after resection were found to be 0.033 0.069/person? year in cases of roentgenographically visible lung cancer, and 0.013-5/ person? year in cases of occult cancer in which all bronchi were not subjected to selective brushings. Regarding cases of roentgenographically visible cancer, 0.9% of the cases were found to be synchronous, and 4.6-6.5% of the cases were found to be metachronous. In cases of roentgenographically occult cancer, 1.7% of the cases not subjected to selective brushings for all bronchi were synchronous, and 10.3 % were metachronous. Of the cases subjected to all bronchi brushings 10.6% were synchronous and 1.5 % were metachronous.
As a result, there is a possibility that most metachronous primary tumor had already become synchronous by the time the initial diagnosis was made. It was indicated that the frequency of synchronous multiple primary lung cancer in cases of roentgenographically visible cancer was almost the same as that in cases of roentgenographically occult lung cancer.View full abstractDownload PDF (1072K) -
Yasuki Saito, Hirotosi Sato, Tadashi Imai, Masami Sato, Shinichiro Ota ...1990 Volume 30 Issue 3 Pages 375-383
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSParticipants who were 50 years of age or older and with a cigarette index of 600 or more were screened annually by both sputum cytology and chest X-ray for the early detection of lung cancer in the Miyagi Program. From 1982 to 1986, 45, 865 person-years were screened. Among 128 men with sputum specimens considered to be positive for cancer cells, 92 cases of lung cancer and 7 cases of upper respiratory tract cancer were confirmed. Among 146 men with sputum spicimens showing susupicious cells or borderline atypical cells, 23 lung cancer were confirmed. One hundred and six cases of these 115 lung cancer cases detected by sputum cytology were squamous cell carcinoma. Among 146 cases of lung cancer detected by dual screening, 92 were detected by sputum cytology only, 23 were detected by both cytology and chest X-ray and 31 were detected by X-ray only. Not only early squamous cell carcinomas of the hilar type but also occult lung cancers located in sub-subsegmental or more distal portions of the bronchi were detected by sputum cytology. The prevalence rate per 1, 000 by the initial screening was 3.4.: 2.2 by cytology only, 0.7 by X-ray only and 0.4 by both examination. The detection rate of lung cancer by sputum cytology at the third or later screening decreased to about a half of the prevalence rate.View full abstractDownload PDF (1073K) -
Noriyoshi Nagamoto, Yasuki Saito, Shinichiro Ohta, Masami Sato, Keiji ...1990 Volume 30 Issue 3 Pages 385-393
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe purpose of this study was to investigate the histogenesis of squamous cell carcinoma of the bronchus. 108 resected specimens of roentgenographically occult lung cancer (ROLC) detected between April 1982 and May 1989 were examined histologically using the method of serial block sectioning at thicknesses of 2 mm. All the initial slides obtained from each block were reviewed. There were 4 carcinomas which involved only one block and were less than 1 mm in section. Some of the initial slides revealed squamous metaplasia with marked atypia or a nest of atypical cells which was suggestive of the presence of carcinoma in the block. These suggestive blocks were serially sectioned entirely. There were 7 tiny carcinomas enclosed within the serial sections. The total of 11 lesions were investigated by careful histological examination concerning the cellular features of the tumor and the morphological changes of the epithelium contiguous to it. Two lesions were situated within a focus of squamous metaplasia with marked atypia and 2 lesions bordered on it. Markedly atypical basal cells were arranged under the tumor and continuously on the basement membrane in 4 lesions. There was one lesion which bordered on the normal appearing epithelium and on basal cell hyperplasia. Two lesions were contiguous only to normal epithelium. There is no denying that squamous cell carcinoma may arise in the normal epithelium. But it was suggested that squamous metaplasia with marked atypia and a line of markedly atypical basal cells can also be the origin of cancer.View full abstractDownload PDF (10277K) -
Shinobu Hatakeyama1990 Volume 30 Issue 3 Pages 395-406
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSRecently, to adoptive immunotherapy of cancer, using lymphokine-activated killer (LAK) cells, has been developed and is used to treat patients with advanced cancer. The most suitable culture condition of cell induction from peripheral blood lymphocyte (PBL) of primary lung cancer patients was studied. Patients consisted of 8 cases of small cell carcinoma, 13 adenocarcinoma, 8 squamous cell carcinoma and 1 of unknown histological type who were not treated with chemotherapeutic agents, and 8 patients who were treated with chemotherapeutic agents. Twelve healthy volunteers were also studied as normal controls. The most adequate concentration of recombinant interleukin 2 (rIL-2) for induction of cytotoxicity of PBL was 2u/ml of TGP-3 and 200u/ml of S-6820, and the suitable culture time was 4-6 days. Anti-tumor effect of LAK cells remained in lung cancer patients treated with anti-cancer drugs as seen in untreated lung cancer patients and healthy volunteers. The concentration of recombinant interferon γ(rIFN γ) to induce maximum anti-tumor effects of PBL was 200u/ml of TRP-2, and the suitable culture time was 48 hours. However, LAK activity did not increase by incubating with rIFN γ. The maximum proliferation of LAK cells induced by and CD3 monoclonal antibody (CD3MoAb) was observed at concentration of 100ng/ml, although that concentration suppressed the LAK activity. On the other hand, 1-10ng/ml of CD3MoAb could induce moderate proliferation of LAK cells and keep the LAK activity. The cytotoxicity of LAK cells was not influenced at all by treating K562 or Daudi cells and PBL bychemotherapeutic agents such as VP-16 and CDDP. The positive rate of Leu 2, 3, 4 and 11 phenotype was increased significantly when PBL changed into LAK cells.View full abstractDownload PDF (1295K) -
Yoshitaka Uchiyama, Koji Kimino, Norio Yamaoka, Shinji Akamine, Satosh ...1990 Volume 30 Issue 3 Pages 407-413
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAmong 366 cases of surgical resected lung cancer, 57 (15.6%) excluding small cell carcinoma, were primary lesions of less than 20 mm in diameter. According to histological type, 19, 33, 2, 3 and one cases were squamous cell carcinoma, adenocarcinoma, large cell carcinoma, carcinoid and adenosquamous cell carcinoma, respectively. By stage, 41, 5, 8 and 3 cases were at stage I, II, III and IV, respectively. The survival rate was 74.7% for stage I cases and 40% for stage II cases at 5 years but stage III and stage IV cases died of relapse within 24 months after resection. Stage III cases showed unfavorable courses. DNA dipl
DNA diploidy in all cases was all at stage I, but DNA aneuploidy was advanced in lung cancer associated with vascular invasion and lymph node metastasis. Concerning vascular invasion, the survival rate was 35.2% for positive cases and 79.8% for negative cases at 5 years. From the standpoint of nuclear DNA content, DNA diploidy and DNA aneuploidy were involved in 12 and 32 (72.7%) cases, respectively. The survival rate was 100% for DNA diploidy and 49.3% for DNA aneuploidy at 5 years, with significant difference (p<0.01) in vascular invasion and nuclear DNA content. The survival rate for DNA aneuploidy and vascular invasion was 18.2% compared with 68.9% for no vascular invasion, with a significant difference (p <0.01), suggesting nuclear DNA content to be an important, independent factor influencing prognosis.View full abstractDownload PDF (793K) -
Akira Yokoyama, Yuzo Kurita, Tetuo Oodaira, Kouiti Kinameri, Masanori ...1990 Volume 30 Issue 3 Pages 415-420
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESScase of early stage adenocarcinoma of the lung originating in a central bronchus was reported. A 63-year-old man was admitted to our hospital complaining of fever. Chest X-ray film showed atelectasis of the right middle lobe. Bronchoscopy demonstrated an irregularly surfaced nodular tumor in the truncus intermedius. Cytology and biopsy revealed well-differentiated papillary adenocarcinoma. Right sleeve middle lobectomy and mediastinal lymphnodes dissection were performed. Macroscopically, a 2×1×1cm nodular tumor was located in the truncus intermedius and confined within the bronchial wall. Microscopic findings of the tumor showed well-differentiated papillary adenocarcinoma with papillary growth into the bronchial lumen, with the tumor replacing the bronchial gland epithelium.View full abstractDownload PDF (9449K) -
Kazushi Hayakawa, Hideaki Miyamoto, Yukitoshi Sato, Enjo Hata, Masanor ...1990 Volume 30 Issue 3 Pages 421-426
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSNausea and vomiting are the most common side effect associated with the use of cisplatinum. We experienced one fatal case of hematemesis caused by Mallory-Weiss syndrome following cisplatinum chemotherapy. Autopsy findings revealed four rents in the gastric mucosa and massive coagula in the stomach. No abnormal findings in other organs could be observed.
Mallory-Weiss syndrome caused by chemotherapeutic agents is unusual and only nine cases have been reported, but it may occur more often in the near future with the widespread use of cisplatinum. Special attention should be paid during the administration of anticancer agents, especially cisplatinum.View full abstractDownload PDF (7121K) -
Masanori Matsumura, Masanori Nishikawa, Hidetada Ikeda, Takao Okubo, T ...1990 Volume 30 Issue 3 Pages 427-432
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 50-year-old woman complained of cough, sputum and lumbar pain. A tumor shadow was pointed out in left 58b and diagnosed as adenocarcinoma of the lung.
She had extensive metastases to the skeleton with marked osteoplastic activities. Subsequently she complained of a headache, therefore lumbar puncture was performed. Since low sugar in the spinal fluid was recognized, meningitis carcinomatosa was suspected, but could not be definitely diagnosed. Though she was treated, she died 8 months therafter.
Autopsy revealed two interesting modes of metastasis of pulmonary adenocarcinoma of the lung. One was marked osteoplastic metastases, and the other was meningeal carcinomatosis without brain metastasis.View full abstractDownload PDF (9968K) -
Comparison with 12Cases of Metastatic Osteomediastinal Tumor (of Thyroid Cancer Origin)Minoru Usui, Kazuko Horie, Sadao Hara, Yoshihiro Horiya, Hiroto Shima, ...1990 Volume 30 Issue 3 Pages 433-440
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe recently made a clinical study of the results of 131I-internal irradiation therapy performed on group I of 14 cases of metastatic lung tumor and group II of 12 cases of metastatic osteo-mediastinal tumor (of thyroid cancer origin), which we have experienced during a period of 7 years from May 1981 to May 1988. For the group I, of 4 cases of 131I-accumulated tissue, 1, 2 and 1 had remarkably effective, effective and ineffective benefits, respectively, and of 10 cases of non-131l-accumulated tissue, 2 and 8 had effective and ineffective benefits, respectively. For the group II, of 5 cases of 131I-accumulated tissue, 4 and 1 had effective and ineffective benefits, respectively, and of 6 cases of non-31I-accumulated tissue, 2 had effective benefits. Mean survival period was 7 years fo1r the group I and 2.5 years for the group II.View full abstractDownload PDF (9759K) -
Yukiko Nakahara, Yasuharu Nakahara, Tadashi Ishida, Rieko Kawanami, Ei ...1990 Volume 30 Issue 3 Pages 441-445
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 38-year-old man complained of cough and sputa. His chest roentgenogram showed a left hilar tumor shadow with an atelectatic upper lobe of the left lung. Bronchoscopic examination revealed a stenotic orifice of the left upper bronchus. Biopsy revealed an adenoid cystic carcinoma involving the stenotic bronchial lesion. In addition, many small yellow-white nodules noticed by bronchoscopy in the trachea throughout bilateral main bronchi were diagnosed histologically as tracheobronchopathia osteoplastica. He has been doing well for eight years after a total pneumonectomy and no remarkable change has been seen bronchoscopically in these osteoplastic lesions.View full abstractDownload PDF (6929K) -
Shoji Sakai, Masataka Ohtsuji, Eiichi Shiina, Yoshio Kasuga, Shiro Tsu ...1990 Volume 30 Issue 3 Pages 447-451
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 69-year-old male heavy smoker with a Brinkman Index of 1000, was admitted to our hospital with a diagnosis of left pneumothorax. No abnormal shadow was revealed by the chest X-ray film taken after recovery from pneumothorax. The sputum cytologic examination on admission showed squamous cell carcinoma. The bronchofiberscopic examination revealed a minute granular surface with slight redness only at the membranous portion of the orifice of the left upper division bronchus. Left upper lobectomy was performed and no carcinoma was seen at the surgical margin of the bronchus.View full abstractDownload PDF (5965K) -
1990 Volume 30 Issue 3 Pages 453-459
Published: June 20, 1990
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (1003K)
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