Abstract
Five cases of hilar type multiple squamous cell carcinoma were studied clinically. Our criteria for accepting two or three separate carcinomas as primary was as follows: 1) Distinct and different bronchial locations, 2) broncho-mucosal origin, with or without mediastinal lymph node involvement. Three lesions were seen in one case, two lesions were seen in the other four cases. In all cases, early cancers without extrabronchial wall invasion were seen, including five roentgenographically occult squamous cell carcinomas.
In one case of unilateral synchronous squamous cell carcinoma, all tumors were curatively resected. In three cases of bilateral synchronous squamous cell carcinoma, the tumor invading the extrabronchial wall was resected surgically and residual early cancers were managed by bronchial arterial infusion, injection of anti-cancer drug bronchoscopically, and/or systemic chemotherapy. In two cases no recurrence was seen in the region of the early cancer treated with non-surgical therapy. One case survived 72 months without recurrence. In one case of metachronous squamous cell carcinoma, the second tumor was completely removed by resection of the left upper trunk.
