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Volume 31, Issue 3
Displaying 1-19 of 19 articles from this issue
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Masahiko Higashiyama, Osamu Doi, Ken Kodama, Ryuhei Tateishi1991 Volume 31 Issue 3 Pages 309-317
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe expression of tissue-type and urokinase-type plasminogen activators was examined in 70 non-small cell lung cancers, using an immunohistochemical method with specific monoclonal antibodies.
Tissue-type plasminogen activator (TPA) was detected in cancer cells of 9 cases (13%) and in the vascular endothelium of 19 cases (27%). The expression of TPA was observed more frequently in small tumors. On the other hand, urokinase-type plasminogen activator (UPA) was detected in cancer cells of 45 cases (64%) and in stromal cells, such as vascular endothelium and fibroblast-like cells, of 44 cases (63%). In some of UPA-positive cases, the strongest staining was present in cancer cells infiltrating the stroma. Moreover, stage I disease patients with UPA-positive tumor had a worse course than UPA-negative patients.
It was concluded that non-small cell lung cancer contains TPA and/or UPA in stromal cells as well as cancer cells. Our observations also suggest that UPA plays an important role in tumor invasion and evolution, providing prognostic information.View full abstractDownload PDF (8758K) -
Sadahide Ono1991 Volume 31 Issue 3 Pages 319-326
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSThe distribution of collagen types I, III, IV and V and procollagen III peptide (P III P) was investigated in 83 cases of lung cancer, using an immunohistochemical technique. A large amount of types I and III collagen was diffusely present in the fibrous stroma of tumors. Alveolar septa trapped in a tumor was also stained with an antibody to type I collagen as well as intact septa. Collagen type IV was demonstrated exclusively in the basement membrane of alveolar septa involved in a tumor. Collagen type V showed patchy staining pattern in alveolar septa in tumors and fibrous stroma of tumors.
Expression of P III P in cancer cells was observed in 54.2%(z15/23 cases) of lung cancers examined in this series. In adenocarcinomas, the incidence of P III P expression was as high as 80%(36/45 cases). Immunoreactivity to and-P III P antibody showed a striking response in well-differentiated adenocarcinomas with papillary growth pattern and with abundant amount of fibrous stroma. These observations support the hypothesis that collagen in stroma of tumors is produced not only by fibroblasts but also by cancer cells.View full abstractDownload PDF (6261K) -
Akihide Matsumura, Kazuya Nakahara, Yoshitaka Fujii, Shinichiro Miyosh ...1991 Volume 31 Issue 3 Pages 327-333
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn the past six years, 9 patients who had undergone resection of primary lung cancer underwent reoperation for intrathoracic recurrence or a new primary lung cancer. Four patients with ipsilateral recurrent disease underwent completion pneumonectomy, and three of them are alive at present without recurrence for 25 to 79 months after the second operation. Two of four patients with contralateral disease had the right upper and lower lobes remaining after the second operation. One of them died of multiple organ failure at the time of abdominal operation five months after the second operation. The other died of metastasis 16 months after the second operation. The remaining two patients with contralateral reoperation had different histologies on the first and the second operation. Tracheal resection was performed in a patient with an endotracheal metastasis. At the time of the second operation, postoperative respiratory complications were experienced in four patients having poor predicted postoperative respiratory function (%VC less than 60% and FEV 1.0 /p-VC less than 40%), but there were no operative deaths.View full abstractDownload PDF (812K) -
Masayuki Nishioka, Masahiro Fukuoka, Syunichi Negoro, Minoru Takada, Y ...1991 Volume 31 Issue 3 Pages 335-341
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSSeventeen patients with unresectable non-small cell lung cancer, were treated by chemotherapy and concurrent chest radiotherapy. Cisplatin (100mg/m2) was given by infusion on day 1 in each course, and vindesine (3mg/m2) was given on days 1 and 8. The patients were irradiated from days 2 to 15 with single doses of 2 Gy. A total dose of 50Gy or more was delivered.
Response to this treatment was evaluable in sixteen patients. Twelve patients showed partial response (response rate=75%), three had no change, and progressive disease was observed in one other case. Among the patients with partial response, four died of cancer, two were alive with recurrent disease, and six are alive without recurrence from 5.5 to 19 months after initiation of the therapy. Myelosuppression was moderate and WBC count nadirs in 20 courses (42%) dropped to less than 1000/mm3. Esophagitis was observed in 19 courses (40%). However, neither treatment-related death nor lifethreatening complications were observed.
It was concluded that cisplatin, vindesine, and concurrent radiation therapy is an effective and tolerable treatment for non-small cell lung cancer, and further studies on this modality are required.View full abstractDownload PDF (766K) -
Hiroshi Niwa, Yousuke Yamakawa, Kei Torii, Toshihiko Urakami, Tsutomu ...1991 Volume 31 Issue 3 Pages 343-349
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSFive cases of hilar type multiple squamous cell carcinoma were studied clinically. Our criteria for accepting two or three separate carcinomas as primary was as follows: 1) Distinct and different bronchial locations, 2) broncho-mucosal origin, with or without mediastinal lymph node involvement. Three lesions were seen in one case, two lesions were seen in the other four cases. In all cases, early cancers without extrabronchial wall invasion were seen, including five roentgenographically occult squamous cell carcinomas.
In one case of unilateral synchronous squamous cell carcinoma, all tumors were curatively resected. In three cases of bilateral synchronous squamous cell carcinoma, the tumor invading the extrabronchial wall was resected surgically and residual early cancers were managed by bronchial arterial infusion, injection of anti-cancer drug bronchoscopically, and/or systemic chemotherapy. In two cases no recurrence was seen in the region of the early cancer treated with non-surgical therapy. One case survived 72 months without recurrence. In one case of metachronous squamous cell carcinoma, the second tumor was completely removed by resection of the left upper trunk.View full abstractDownload PDF (790K) -
Is “Non-Small Cell Lung Cancer” HomogeneousTsuyoshi Hasegawa, [in Japanese], [in Japanese], Nobuyuki Katakami, [i ...1991 Volume 31 Issue 3 Pages 351-357
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe performed a multi-institutional phase II trial of combination chemotherapy with mytomycin C (8mg/m2, day 1), vindesine (3mg/m2, day 1 and 6) and cisplatin (90mg/m2, day 1) for advanced non-small cell lung cancer.
Between July, 1986 and June, 1988, 119 patients were enrolled and 101 were fully evaluable. Among 101 evaluable cases, there were 59 adenocarcinomas, 27 squamous cell carcinomas, 13 large cell carcinomas, one adenosquamous cell carcinoma, and one unclassified non-small cell lung cancer. There were significantly larger number of stage IV patients in adenocarcinoma. There was no complete response and 41 partial responses. The overall response rate was 41%. The response rate of adenocarcinoma was significantly lower than that of squamous cell carcinoma and large cell carcinoma (p<0.01 and p<0.05, respectively). There was significant difference in the response rate between adenocarcinoma and squamous cell carcinoma in both stage III and stage IV diseases. There was no significant difference in the response rate according to clinical stage and PS. Toxicities were manageable and tolerable.
The MVC regimen showed an acceptable response rate and tolerable toxicity for advanced non-small cell lung cancer. Adenocarcinoma had less sensitivity to this regimen compared to other non-small cell lung cancer. More attention should be paid to the histological subclass of non-small cell lung cancer in future clinical trials.View full abstractDownload PDF (800K) -
Yoshihiro Nambu, Takekuni Iwata, Kazukiyo Oida, Yoshiaki Kohri, Yoshio ...1991 Volume 31 Issue 3 Pages 359-365
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSWe investigated double cancer in 1, 516 patients with malignant neoplasms, including 359 with lung cancer and 1, 157 with non-pulmonary malignant neoplasm, autopsied at Tenri Hospital between 1966 and 1986. Double cancer was found in 90 of these 1, 516, in 38 (10.6%) of the lung cancer patients and 52 (4.5%) of patients with non-pulmonary neoplasms. The incidence of double cancer including lung cancer was significantly higher than that of double cancer without lung involvement (< 0.01, X2 test). Cancers that accompanied lung cancer included prostatic cancer (12, including 9 with occult cancer), gastric cancer (11), pulmonary double cancer (7), malignant lymphoma (3) and others. The age and male-female ratio tended to be higher among lung cancer patients with double cancer than among all lung cancer patients. In terms of histologic type of lung cancer, no significant difference was noted between lung cancer patients with double cancer and all lung cancer patients. Analysis of background variables revealed that in 2 (28.6%) of the 7 patients with pulmonary double cancer the cancer had been complicated by idiopathic interstitial pneumonia. Of the 38 lung cancer patients with double cancer including lung cancer, double cancer was detected in 19 at postmortem examination.
Although the second cancer was frequently subclinical in the present study, the higher incidence of double cancer among autopsied patients with lung cancer indicates the necessity for special attention to the possibility of double cancer in the diagnosis and treatment of lung cancer.View full abstractDownload PDF (863K) -
Tadashige Fujii, Masao Tanaka, Tatsuya Nakatsuka, Kazuhiko Yoshimura, ...1991 Volume 31 Issue 3 Pages 367-376
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSUsing perfusion lung scintigraphy with Tc-99 m MAA, pulmonary perfusion in the contralateral lung of the primary focus was analyzed in 425 cases with primary lung cancer. Perfusion abnormalities in the contralateral lung were observed in 318 of 425 cases (74.8%), and the causes of hypoperfusion were known in 210 cases (66.0%) and unknown in 108 cases (34.0%). Hypoperfusion due to carcinomatous causes, in which intrapulmonary metastasis was the most frequent, was observed in 154 cases and more frequently in cases with adenocarcinoma, T3, N2, Ml, and stage 4 by TNM staging. Hypoperfusion due to non-carcinomatous causes, in which pleural thickening or adhesion was the most frequent, was observed in 172 cases. Hypoperfusion of unknown causes was found more frequently in cases with squamous cell carcinoma, small cell carcinoma, T3, N1, N2, stage 2, 3 and 4 by TNM staging and elevated serum fibrin degradation products. In 119 autopsied cases, various changes of the intrathoracic organs were revealed, and incidences of some changes in the contralateral hemithorax of the primary focus, such as intrapulmonary metastasis, bronchopneumonia, non-specific pleurisy and pulmonary embolism, were approximately equal to those in the ipsilateral hemithorax.
Perfusion lung scintigraphy is of special significance to understand the disease process and pathophysiology of pulmonary perfusion, and especially to estimate pulmonary perfusion abnormality in the contralateral lung of the primary focus, which could reveal various intrathoracic changes of carcinomatous and non-carcinomatous origins.View full abstractDownload PDF (6272K) -
Yoshifumi Miyamoto, Sakan Maeda, Noboru Ishii, Ryuta Aogauti1991 Volume 31 Issue 3 Pages 377-383
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSOne of the major technical problems which has not been solved in the clonogenic hemosensitivity testing is the lack of sufficient growth conditions for cancer cells in vitro. The authors have been engaged in searching for better growth conditions for lung cancer cells using cell lines and we found that the addition of 5μg/ml transferrin, 1×10-3 M L-cysteine, and 5×10-5M bathocuproine disulfonate (BCS), which were used in establishing malignant lymphoma cell lines by Epstein et al, significantly enhanced the colony formation of 5 small cell lung cancer (SCLC) cell lines. However, no improvement in the colony formation of 5 non-SCLC cell lines was seen by addition of these supplements. The analysis of all possible combinations of these three supplements showed that combined addition of L-cysteine and BCS played the most important role in this colony growth stimulating effect on SCLC cell lines. Transferrin had only a small additive effect, probably because of the use of serum supplemented medium in this experiment. The dose-response curve showed that these supplements produced marked increase in the cloning efficiencies of SCLC cell lines at very narrow concentration ranges. In contrast to the clonal growth, the proliferation of SCLC cell line PC-6 in liquid culture was suppressed by these supplements.
Although many difficulties still remain before the development of a chemosensitivity test which can be used routinely, our results provide new knowledge on the clonal growth of SCLC cells and have some value concerning the clonogenic chemosensitivity testing of SCLC.View full abstractDownload PDF (813K) -
Hideo Manabe, Jun Miyake, Akio Horie, Masamitsu Kido, Tohru Tsuda, Tak ...1991 Volume 31 Issue 3 Pages 385-389
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIt is believed that lung cancer in the young is more progressive, more resistant to any therapy and more fatal.From another point of view, lung cancer in the young is suspected to be independent of environmental carcinogens such as cigarettes.The author treated 12 lung cancer patients younger than 30 years old in the past 10 years, and studied clinical features of these patients and reviewed the literature.
Three patients were men and nine were women (ratio=1: 3) and only 4 patients smoked, none heavily.There were 2 tracheal tumors, 2 hilar tumors and 8 peripheral lesions.The most common histopathological type was adenocarcinoma (6 cases) and there were 3 bronchial gland origin tumors.Four patients, including 2 bronchial origin tumors are alive, and the mean survival time of the 7 patients who died of cancer was 9.6 months.
It was concluded that the incidence among females is high, that adenocarcinoma is most common histopathologically, that bronchial gland origin tumor is seen most frequently, and that the prognosis of lung cancer in the young was similar to other lung cancers.View full abstractDownload PDF (528K) -
Eiichi Akaogi, Kiyofumi Mitsui, Tomoo Kinoshita, Hiroshi Yuasa, Osamu ...1991 Volume 31 Issue 3 Pages 391-396
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAbnormal squamous cells were detected in a 73-year-old male by sputum massscreening. Since chest roentgenogram and bronchoscopic examination revealed no abnormality, follow-up was commenced. Three months later, a small cavity shadow appeared on his chest roentgenogram and another three months later, the thin-walled cavity had expanded. Bronchial brushing cytology of the lesion revealed keratinizing squamous cellcarcinoma and left lower lobectomy was performed. Histological examination of the resected specimen suggested that the cavity was produced chiefly by a check-valve occlusion of the bronchus involved with the tumor.
Any case of roentgenologically and bronchoscopically occult lung cancer should be followed up at least every three months during the initial period of follow-up.View full abstractDownload PDF (6984K) -
Kazutoshi Sugito, Nobuhiro Tanabe, Tetsuya Sakuma, Kenzo Hiroshima, Ke ...1991 Volume 31 Issue 3 Pages 397-402
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 72-year-old female was admitted to our hospital because of bronchorrhea and diffuse infiltrative shadows on chest x-ray. The TBLB specimens suggested adenocarcinoma with a bronchiolo-alveolar pattern. This case was clinically diagnosed as bronchiolo-alveolar cell carcinoma. Corticosteroids were not effective and she died of respiratory failure about 3 months after the admission. Autopsy findings showed a 5×4×2cm mass at the tail of the pancreas. The specimens obtained from the lung tissue showed tumor cells growing as a single layer along alveolar walls. The features of the lesion in the lung were pathologically similar to those of the lesion in the tail of the pancreas. Further examination revealed metastatic pulmonary adenocarcinoma of pancreatic origin. Comparative analyses of biochemical components in sputum in this case and previous reports showed that levels of fucose, albumin, and DNA were low in this case. It was suggested that this excessive production of sputum was due to abnormal secretion of tumor cells rather than exudation of plasma constituents and inflammatory change in the airways.View full abstractDownload PDF (1050K) -
Michio Hirasawa, Yasuhito Honda, Takuya Fujishima, Tomofumi Igarasi, M ...1991 Volume 31 Issue 3 Pages 403-408
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 69-year-old man, a heavy smoker, was admitted to our hospital because of malignant squamous cells in sputum, without any abnormal shadow on the chest X-ray film. Bronchoscopy revealed a white solitary polypoid tumor at the bifurcation between left B1+2a+b and B1+2c, which was histologically diagnosed as solitary papilloma of the bronchus. Four months later, a squamous cell carcinoma in the right middle bronchus was found by follow-up endoscopy, and a right middle lobectomy was carried out. The tumor was completely resected. On follow-up endoscopy after the operation, a second squamous cell carcinoma in the right upper bronchus and a third squamous cell carcinoma in the upper trachea were revealed. Laser treatment and irradiation were performed for the second and third carcinomas.View full abstractDownload PDF (10666K) -
Hironori Tanaka, Kazuko Ito, Masanobu Hayashi, Tomoki Tashiro, Gou Ito ...1991 Volume 31 Issue 3 Pages 409-413
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn a 64-year-old male with bloody sputum and dyspnea, bronchoscopic examination revealed a polypoid small cell carcinoma obstructing the left main bronchus. After 44 Gy Linac irradiation, the polyp was removed bronchoscopically. Preoperative examination indicated no lymph node or distant metastases. Left upper sleeve lobectomy was performed. The tumor originated at the bifurcation of the left upper division and lingular bronchus. Histologically, the tumor was shown not to invade beyond the bronchial wall and there was no lymph node metastasis. Intensive chemotherapy failed due to leukopenia. At 4 months after the operation, metastasis to lumbar vertebrae developed and at 8 months, the patient died. Intensive chemotherapy should be conducted in early stage small cell carcinoma.View full abstractDownload PDF (6837K) -
Hirohito Morita, Hirokuni Yoshimura, Saburo Hirai, Jyun Shinada, Akira ...1991 Volume 31 Issue 3 Pages 415-420
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSAn immature teratoma with a component of yolk sac tumor originated from the anterior mediastinum. After preoperative chemotherapy including the administration of CDDP, VP-16, VLB and BLM, pleuropneumonectomy with partial resection of the superior vena cava was performed. The tumor was completely removed and postoperative chemotherapy including administration of CDDP and VDS was performed. The maximum level of serum AFP peaked at 24, 000ng/ml before operation but decreased to a minute amount below 3.0ng/ml after chemotherapy and operation. Continued follow-ups revealed no recurrence for 27 months after surgery. Cases of yolk sac tumor are known to have poor prognosis. We believe that the controlled administration of chemotherapy and pleuropneumonectomy improved the prognosis.View full abstractDownload PDF (9495K) -
Toru Enokibori, Atsushi Katsura, Mareki Yagisawa, Yuji Yasuda, Hirofum ...1991 Volume 31 Issue 3 Pages 421-426
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSA 67-year-old woman who had received maintenance hemodialysis for 16 years was admitted for an abnormality on chest X-ray and chest pain. Bronchofiberscopic examination was carried out and adenocarcinoma was confirmed by transbronchial lung biopsy (TBLB). After hemodialysis and blood transfusion for three days, left upper pulmonary lobectomy was performed under general anesthesia. Perioperatively, a vasodilator and calcium-antagonist were administered for angina pectoris, and the operation was completed satisfactorily. On the first postoperative day, hemodialysis with gabexate mesilate (FOY) instead of heparin was performed, and there was no postoperative bleeding. The postoperative course was uneventful, and she was discharged a month after the operation. She is alive 24 months after the operation and has had no recurrence. In lung cancer patients on maintenance hemodialysis, pulmonary resection should be performed taking proper preoperative, perioperative and postoperative precautions.View full abstractDownload PDF (5714K) -
Hisako Hasimoto, Muneaki Waku, Akira Koyama, Yosinori Kawabata1991 Volume 31 Issue 3 Pages 427-433
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
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Kiyoshi Komuta, Keiji Maeda, Tuyoshi Igarashi, Shigeru Okamoto, Ichiro ...1991 Volume 31 Issue 3 Pages 435-439
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSIn this case of amylase-producing lung cancer, uveal tumor was suspected in a 52-year old female patient with decreasing visual acuity. Chest roentgenograms showed a mass shadow in the superior basal segment of the left lower lobe and disseminated nodular shadows in the entire lung. Biopsy specimen obtained by bronchoscopy revealed adenocarcinoma of the lung. The tumors on the ocular fundus were thus believed to be metastases of lung cancer. Amylase activity in serum was markedly elevated, and the amylase isoenzyme pattern indicated a salivary origin. Amylase activity in the homogenate of tumor tissues obtained by autopsy was also elevated when compared with normal muscle tissue. This demonstrated that this case was an amylase-producing lung cancer.View full abstractDownload PDF (6201K) -
1991 Volume 31 Issue 3 Pages 441-462
Published: June 20, 1991
Released on J-STAGE: August 10, 2011
JOURNAL FREE ACCESSDownload PDF (3198K)
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