1995 Volume 35 Issue 2 Pages 187-193
A 65-year-old man was admitted to our hospital because of cough, fever and left chest pain. A chest X-ray film showed a tumor shadow in the left hilum and findings suggestive of obstructive pneumonia in the left upper lobe. Bronchofiberscopy revealed large cell carcinoma of the lung. Because metastatic subcutaneous lesions were detected, we performed chemotherapy and radiotherapy, but the patient died as a result of respiratory failure. The white blood cell count rose to 83, 600/mm3 and the serum granulocyte colony-stimulating factor (G-CSF) level increased to 5, 237pg/ml as the tumor grew. An immunoperoxidase study showed that the tumor cells of the autopsied specimen stained positively with specific monoclonal antibodies against G-CSF. These findings indicated production of G-CSF by the tumor cells.
