Transformations of Alkynes Catalyzed by t-Bu-P4 Base

Abstract

ransformations of alkynes using catalytic amount of t-Bu–P4 base were accomplished. Additions of alcohols and an amine to alkynes were promoted by cat. t-Bu–P4 base under relatively mild reaction conditions, and desired vinyl ethers and an enamine were obtained in good yields. A dimerization of terminal alkynes via C–H activation proceeded with cat. t-Bu–P4 base and an amine as additive, and a conjugated enyne product was obtained. The first catalytic enyne synthesis via alkyne dimerization catalyzed by organic catalyst was performed. NMR studies on reaction species of C–H activation of terminal alkynes with t-Bu–P4 base were also carried out.