円二色性吸収スペクトルを用いる固相不斉触媒の迅速解析システム

抄録

Combinatorial approaches toward the exploration of novel asymmetric catalysts require a convenient high-throughput screening (HTS) for analyzing both of catalyst activity (i.e. chemical yield) and enantiomeric excess. A new HTS system was developed by coupling a circular dichroism (CD) detection and solid phase reactions. In the asymmetric solid catalysts, as far as the asymmetric induction is not produced by the catalysts, no significant CD-signal should be detected in the analysis of solution phase. Based on this principle, the newly developed HTS has been demonstrated in the model reaction of oxidative coupling of β-naphthol. After carrying out the asymmetric reaction, the reaction mixture of solution phase was directly introduced to the CD detector without use of chromatographic separation. The HTS system allowed the wide range analysis of relative efficiency of the catalyst activity and asymmetric induction.

Figure 1