Photoaffinity beads containing aryl diazirine as a photoreactive group at the termini of the TentaGel resin were designed and prepared for affinity capture of proteins. The immobilization of compounds on the resin was easily achieved by UV irradiation. The DNA polymerase β inhibitors were immobilized on the photoaffinity beads by photoreaction. DNA polymerase β was successfully bound by the immobilized DNA polymerase β inhibitors.
