主催: 日本薬学会化学系薬学部会
Sialic acid is one of the most important compounds on carbohydrate chemistry. Our recent research interest has focused on the chemical property elucidation of the double bond in 2-deoxy-N-acetylneuramic acid (Neu5Ac2en). Neu5Ac2en consisting with glycal structure is chemically a very stable compound compared with glucal. However, reduction compound of carboxyl group on Neu5Ac1Me, 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enitol (3), change into the compound with a very high reactivity. When treating under an acid condition in methanol, 3 gave a lot of products as shown in scheme 3. It was shown that the chemistry of double bond of 3 looks like similarly glucal.