硫黄イリドによるビシクロ[2.2.1]骨格を有する6, 14-エポキシモルヒナンの合成　

抄録

The conversion of the message site of the skeleton of naltrexone was carried out to improve the selectivity for opioid κ,δ, ε receptors and their subtypes. The naltrexone derivatives without 4,5-epoxy ring reacted with a sulfur ylide to afford a novel 6,14-epoxymorphynann having five membered ring ether. We will also report syntheses of various derivatives with this novel skeleton for obtaining opioid receptor subtype selective ligand.

fig.1