触媒的環化アルケニル化反応とスズを使わないラジカル転位反応を組合せた神経保護物質セロフェンド酸の不斉全合成

抄録

Total syntheses of serofendic acids A (1a) and B (1b) are described. The key strategic element of the approach involves the novel tin-free homoallyl-homoallyl radical rearrangement of 5 for the construction of bicyclo[2.2.2]octane ring system 4. In addition, the conversion of methyl atisirenoate 2 to serofendic acids A (1a) and B (1b) was achieved on the basis of the Michael reaction of sodium thiomethoxide. The methodology developed here should also provide access to synthetic analogs of serofendic acids (1).

fig.1