抄録
We have successfully verified that dehydrocondensation is ideally suited for micellar reaction. A bimolecular dehydrocondensation between amphiphilic carboxylate anions and amines was highly accelerated (2,000-fold) in a micellar system when a 1,3,5-triazine-type amphiphilic dehydrocondensing agent was used. Such an unusual rate enhancement of dehydrocondensation can be attributed to increased local concentration of substrates and a preorientational effect of the micelles on the amphiphilic dehydrocondensing reagent, the carboxylate, and the amine. It should be noted that the catalytic dehydrocondensation involving the activation of carboxylic acids takes place at the interface between water and the micelles, not in the hydrophobic interior of the micelles.
