トリクロロシランの高効率活性化剤の開発と利用

抄録

Enantioselelctive reduction of ketones and imines has been one of major topics in asymmetric synthesis. One of recent interesting reducing reagents is trichlorosilane (Cl3SiH), which is a liquid material easily available from silicon industry. However, some activator is necessary for Cl3SiH to efficiently reduce ketones and imines. We already reported some chiral N-formylpyrrolidine derivatives as organic activators in enantioselective reduction of ketones and imines by Cl3SiH, although the enantioselectivity was low to moderate. In our continuing effort to exploit new chiral organic activators, we found new highly effective pyrrolidine derivatives to reduce aromatic ketones and aromatic imines (up to 97%ee for ketones and up to 80%ee for imines).

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