新規インフルエンザ治療薬開発を志向したフラン融合化合物のデザイン、合成、および活性評価

抄録

We have accomplished a synthesis of various furan-fused compounds using tandem electrocyclic reaction of benzocyclobutene derivatives, including o-quinodimethane formation and inverse electron demand Diels-Alder reaction. This synthetic method has several advantageous features such as high generality, short-step sequence, and high stereoselectivity. These furan-fused compounds exhibited antiviral activity against influenza A virus, and favorably showed low cytotoxicity. Moreover, these compounds exhibited the activity against influenza B virus, which is different property from amantadine.

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