抄録
Recently, we have established the novel synthetic method of the trimer with a rigid 1,3,5-trioxazatriquinane skeleton using a nitrogen clamp. The designed homotrimer derived from acetophenone derivatives 1 bound to opioid receptor. The above results led us to the synthesis of heterotrimer. One of the heterotrimers 3 with anisole unit was successfully synthesized using glycoaldehyde dimer 2.
We will report the detail of synthesis of heterotrimers and their pharmacologies.
