対称分岐型オリゴグリセロールによる医薬品の薬効改善

抄録

We have developed symmetrically branched oligoglycerols (BGL) such as dimer (BGL002) and trimer (BGL003) as G2, hexamer (BGL006) and heptamers (BGL007) as G3, and dodecamer (BGL012) and tetradecamer (BGL014) as G4 dendrons. BGL family possess 2ⁿ (n = 1—3) of primary hydroxides at terminal region for water-solubilizing and⁄or water-affinity, and OH, NH, NH₂, or N₃ group and further linkered structures at apex region for the covalent bond formation of various molecules (BGLation) such as poorly water-soluble medicines or molecules with poorly water-affinity. We report chemistry of BGLations and the property of the resulting BGLated derivatives such as fibrates, paclitaxel, p-borophenylalanine, piceatannnol, artificial protein drug and liposome.