パラジウム触媒を用いたプロパルギルβ-ケトエステルの連続反応による置換フランの合成

抄録

Palladium-catalyzed decarboxylative allylation of allyl β-keto esters can be carried out under extremely mild conditions, a variety of applications have been reported. In contrast to the extensive studies on the reactions of allyl β-ketoesters, no examples have been reported on the reactivity of propargyl β-keto esters with palladium. We report the palladium-catalyzed reaction of propargyl β-keto esters. This process produces tetra-substituted furans having a variety of substituents via a decarboxylative [3+2] cyclization pathway. Since many biological active natural products and industrially useful compounds having a furan component have been reported, our methodology would provide a new protocol for the synthesis of these compounds with high efficienct.