Abstract
In general, chemotherapeutic agents show remarkable absorption of ultra violet region. This absorption is known as the result of resonance produced in the intermolecular vibration.
we studied on the chemotherapeutic agent for lepra and tuberculosis to compare with oridinary sulfon amide preparation in the point of view of medium pH. The results are as follow:
Jt is noted that these agents show 2 remarkable absorption maxima at 260mμ and between 280-300mμ. The absorption at 260mμ is certified to due to the intermolecular vibration of basic amino radical which is contained in the almost all chemotherapeutic agents, and this absorption is hold in the acidified medium, while in ordinary sulfon amide preparation this absorption is notably reluced. It might be said that chemotherapeutic agents for so called Saurefest bacteria offer strong resitance to the change of medium from neutral to acid. This resistance is believed due to the free amino radical in that agent.
