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Volume 20 (1951)
- Issue 6 Pages 173-
- Issue 5 Pages 136-
- Issue 4 Pages 97-
- Issue 3 Pages 63-
- Issue 1 Pages 1-
Volume 20, Issue 4
Displaying 1-9 of 9 articles from this issue
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YOSHIMASA WATANABE1951 Volume 20 Issue 4 Pages 97-98
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe cultivation of Stephansky's bacilli on my devised and Nakamura's media presented many bacilli at the first generation, but they decreased and disappeared at the second and the third generations. The inoculation of these bacilli to rats, to discriminate the alive from the dead, informed us that the bacilli, whicn had been recognized of a large number at the first generation, were dead after 60 days on the media. On mucin media they were not found dead till 80 days, therefore, the mucin media may keep bacilli alive longer than any other ones, but did not allow them to proliferate.View full abstractDownload PDF (147K) -
IIII. SUMMARY AND DISCUSSIONKazuo Saikawa1951 Volume 20 Issue 4 Pages 99-105
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSI stutied the peripheral Nerve and skin in the various clinical phases of Leprosy examined by Mitsuda's reaktion by means of biopsy. These objects are the early stage of nodular, neural and macularr leprosy; erythema nodosum leprosum; acute infiltration; acute exacerb-ation; transitional stage from neural to nodular leprosy; obsolate neural leprosy; Mitsuda's reaction positived nodural leprosy.
The important results are following;
1. There is an intensive affinity between nervus fibers and lepra bacillus and in the extremely early stage of leprosy the bacillus exsist there: And bacillus is latent there for a long time in spite of continual treatment.
2. The histo-pathological changes on the peripheral nerve and skin are generally the same character.
3. The hito-pathological change of peripheral nerve between nodural and neural-macular leprosy is essentially different.
4. About the degeneration of the nerves fiber, I can not find difference by the lepra type.
5. I find two cases of nervus abscess in macular leprosy and one case of calcification in neural leprosy in this study.View full abstractDownload PDF (1706K) -
Kenji Yasumoto1951 Volume 20 Issue 4 Pages 106-108
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe material of this experiment was three groups of four rats. The first group was administered 25mg of P. A. S., the second 0.3mg of tibione, daily for 60 bays by mouth and the third was used as control. The results revealed that both drugs had conciderable toxitic manifestation, but suppressed the murine disease. There could be seen no effect on the morphological changes of bacilli in vitro.View full abstractDownload PDF (197K) -
Masahiro Nakamura, Masahisa Shingu1951 Volume 20 Issue 4 Pages 109-112
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThree groups of six rats were used. The first was iniected promin subcutaneously, the second through veins and the rest was a control group. Injections were administered 48 tunes and observation was for 4 months. Both subcutaneous and intravenous injections could not suppress the disease and produced no difference of lepromata in size. But it was interesting that the intraveneous group showed no or very slight lesion on skin. In short, protomin has not so remarkable an effect on murine leprosy as on human leprosy.View full abstractDownload PDF (287K) -
T. Imakita, M. Kono, R. Kageyama1951 Volume 20 Issue 4 Pages 113-117
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSIn general, chemotherapeutic agents show remarkable absorption of ultra violet region. This absorption is known as the result of resonance produced in the intermolecular vibration.
we studied on the chemotherapeutic agent for lepra and tuberculosis to compare with oridinary sulfon amide preparation in the point of view of medium pH. The results are as follow:
Jt is noted that these agents show 2 remarkable absorption maxima at 260mμ and between 280-300mμ. The absorption at 260mμ is certified to due to the intermolecular vibration of basic amino radical which is contained in the almost all chemotherapeutic agents, and this absorption is hold in the acidified medium, while in ordinary sulfon amide preparation this absorption is notably reluced. It might be said that chemotherapeutic agents for so called Saurefest bacteria offer strong resitance to the change of medium from neutral to acid. This resistance is believed due to the free amino radical in that agent.View full abstractDownload PDF (167K) -
Masahiro Nakamura, Masahisa Shingu1951 Volume 20 Issue 4 Pages 118-122
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe intraperitoneal inoculation of murine bacilli revealed us that they appeared and proliferated in liver, spleen and kidney after a week, and were diseeminated into every lymphoglands or other organs in the course of time, but most remarkably proliferated in spleen and omentum major. They could not be found in brain. Their proliferating type as general acid fast bacilli.View full abstractDownload PDF (344K) -
Shinnosuke Oshima1951 Volume 20 Issue 4 Pages 121-124
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThis paper presents the effects of 100 cases of refrigerated skin transplantation admin-istered on 72 patient. It produced striking results on neuralgia and paresthesia due to leprosy, and was effecitve somewhat on asthma, but not on erythema nodosum leprosum, malurn perforans pedis or ulcer at all. We recognized no relation between the effectiveness of the operation and the sized of transplantanted skin, time of refrigerating, the existence of hypostnesia, sexes, disease types and blood sedimentation velocity.View full abstractDownload PDF (338K) -
Yukimasa Kitami1951 Volume 20 Issue 4 Pages 125-127
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe saliva was collected from both parotis, glandula sublingualis et submaxillaris of 339 lepra nodosa, of 85 l. nervosa and 14 l. maculosa and thier pH was measured with the paper method. Parotis saliva was always acidic, sublingual and submaxillar saliva weak acidic and nearer to neutral. Male saliva was higher in acidity and female was near neutral. As for the disease types, it was highest in acidity with lepra nodosa, then followed 1, nervosa and 1, maculosa was lowest and near neutral.View full abstractDownload PDF (240K) -
Hajime Honda, Kazumasa Yoshino1951 Volume 20 Issue 4 Pages 128-132
Published: July 20, 1951
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSBrowning' s Wassermann reaction and complement binding reaction of leprous and syphilitic serum with antigen of many ratios of cardiolipin (NISSIN), kephalin and choles-terin gave us the following results : the antigen of cardiolipin (1), kephalin (30), and cholesterin (15), produced positive reaction with 57% of leprous serum (lepra tuberosa 75%, L. nervosa 25%, and L. maculosa 67%), but with only 10% with syphlitic serum.View full abstractDownload PDF (291K)
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