EFFECT OF ANTIBIOTICS ON MURINE LEPROSY

Abstract

Experimental studies were carried out on the inhibitory action of antibiotics on development of murine leprosy. Those antibiotics, Acidomycin (AM) (Thiazolidone Antibiotics of McLamor et al.), Streptomycin (SM) and Aureomycin (AUM) were studied and the results are presented below.
1. Acidomycin does not have an inhibitory action on the development of murine leprosy. (Fig. 1, 3 and 4)
2. Streptomycin has a moderate inhibitory effect on the development of murine leprosy. (Fig. 2, 3 and 4)
3. Aureomycin possesses no inhibitory action on the development of murine leprosy. (Fig. 5)
From these results and the results of previous studies chemotherapeutic agents, it is believed that antibiotics which are ineffective in experimental tuberculosis are also in- effective in preventing development of murine leprosy.