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Volume 23 (1954)
- Issue 6 Pages 319-
- Issue 5 Pages 251-
- Issue 3 Pages 93-
- Issue 2 Pages 52-
- Issue 1 Pages 1-
Volume 23, Issue 2
Displaying 1-8 of 8 articles from this issue
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Report 1. On the Growth of M. leprae murium in Lecithin-contained MediumTADAO TODA, ICHIJI MIFUCHI1954 Volume 23 Issue 2 Pages 52-56
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThe media used for cultivation of M. leprae murium were based on the modified Kirchner's medium and contained polytamin, and glycerin, dextrose, soluble starch or glycogen was added to it as carbon source. Chemically pure lecithin and blood albumin were added to it for supplementary purposes.
It seemed that M. leprae murium could be grown on starch or glycogen-lecithinalbumin added medium at the initial culture and at the first subculture, but further subcultures were found impossible on this medium. The growth of M. leprae murium was worse on dextrose-lecithin-albumin medium, and worst on glycerin medium.View full abstractDownload PDF (672K) -
AKIRA YAMAOKA1954 Volume 23 Issue 2 Pages 56-63
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSThe author made electron-microscopic specimens from homogenates of the Human Leprosy Nodule (Leprom) which had been aseptically removed and observed electron-microscopically. The results are as follows:
(1) The size and shape of M. leprae under electron-microscopic observation are approximately identical with an optical view after strong staining (Fig. 5-22).
(2) Although different specimen making process from the case of optical microscope were adopted, identical images with old optical observation were gained as regards the arrangement of bacilli: M. leprae were placed alone, gathered irregularly, placed side by side like cigar bundles or gathered in round masses. These views were identical with optical observation (Fig. 5-22).
(3) Two types were found in M. leprae morphologically, one is a granular type and the other homogeneous. In granular type, the bacilli which have dense masses that appear like large polar bodies are predominant (Fig. 3 and 4, 5-22).
(4) Some bacilli have a belt-like structure covering almost equal to the width of bacilli. But the nature of this structure is still left unknown (Fig. 21 and 22).
(5) It was observed that in some bacilli there were small round bodies (150-200 mμ in diameter) like the flowers of chrysanthemum inside or outside the bacilli. These small bodies are being studied (Fig. 8).
This report was presented at the Conference of West District, Leprosy Society of Japan, Hiroshima, November 8, 1953.View full abstractDownload PDF (1610K) -
YOICHIRO KAWAGUCHI1954 Volume 23 Issue 2 Pages 64-68
Published: March 20, 1954
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSThe present paper describes the results of hemagglutination test with tuberculinsensitized red cells on the sera of the white rats inoculated with the rat leprosy bacilli.
1) Experiment A. Fifteen of 16 infected animals showed positive reaction, with the hemagglutination titres being from 1: 4 to 1:128.
2) Experiment B. In the early stages of the infection, all the sera of inoculated animals demonstrated negative reactions. Only the two animals became positive 6 months after inoculation.
3) Hemagglutination titres seem not to correlate with the weight of superficial leproma, but to the grade of leprous changes of visceral organs.View full abstractDownload PDF (370K) -
Report I On the Synthesis of PAShydrazide and its Influence on Murine LeprosyTOSHIO YOSHINAGA, TENMIN KAKU1954 Volume 23 Issue 2 Pages 68-71
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESS1. We synthesized PAShydrazide for the treatment of leprosy.
2. PAShydrazide prevents tolerably. the development of murine leprosy
3. The effect of Pashydrazide upon murine leprosy is almost the same as that of PAS or INAH.View full abstractDownload PDF (469K) -
Studies on Rat Leprosy (25)YASURO TAKAYAMA1954 Volume 23 Issue 2 Pages 71-74
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSEvaluating the influence of INAH on rat leprosy, based upon the degree of enlargmert of leproma and dissmlnation of leprosy bacilli into tissues, it seemes to be much or less active for the inhibition of the development of and therapeutic effect on rat leprosy in hamster.View full abstractDownload PDF (545K) -
SHINJI NISHIMURA, MICHIYUKI KONO, TARO MASUDA1954 Volume 23 Issue 2 Pages 74-81
Published: March 20, 1954
Released on J-STAGE: June 30, 2008
JOURNAL FREE ACCESSExperimental studies were carried out on the inhibitory action of antibiotics on development of murine leprosy. Those antibiotics, Acidomycin (AM) (Thiazolidone Antibiotics of McLamor et al.), Streptomycin (SM) and Aureomycin (AUM) were studied and the results are presented below.
1. Acidomycin does not have an inhibitory action on the development of murine leprosy. (Fig. 1, 3 and 4)
2. Streptomycin has a moderate inhibitory effect on the development of murine leprosy. (Fig. 2, 3 and 4)
3. Aureomycin possesses no inhibitory action on the development of murine leprosy. (Fig. 5)
From these results and the results of previous studies chemotherapeutic agents, it is believed that antibiotics which are ineffective in experimental tuberculosis are also in- effective in preventing development of murine leprosy.View full abstractDownload PDF (502K) -
HAJIME NAKASHIMA1954 Volume 23 Issue 2 Pages 81-84
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSI have studied on the therapeutic effects of proethyl in relation to the development of rat leprosy. The results were as follows.
1) The mortal dose of proethyl is DL 50-93. 64mg/10 gr by subcutaneous injection of this drug and DL 50-442.5mg /10gr by its internal dosage.
2) The density of proethyl in blood was appeared the highest after the internal dosage during 2 hours, and half degrees after 5 hours. This density of proethyl could be measured by 24 hours.
3) The therapeutic effectiveness of this drug on rat leprosy was based upon the degree of the enlargement of leproma and the dissemination of lepra bacilli into tissues. It was appeared a little effect on rat leprosy.View full abstractDownload PDF (489K) -
OEI UMEKI1954 Volume 23 Issue 2 Pages 85-90
Published: March 20, 1954
Released on J-STAGE: December 10, 2008
JOURNAL FREE ACCESSTwenty leprous patients with neuralgia and arthrodynia were treated with Nitromin by intravanous or local injection.
It was remarkably effective in 12 cases, moderatly in 2 cases, but ineffective in 3 cases and the effect was indefinite in another 3 cases.View full abstractDownload PDF (801K)
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