Abstract
A relatively small quantities of TB1 and INAH were administered. TB1 produced an excellent effect. In this paper, the treatment effect and experimental results of resorption, discharge and organ concentrations of these two chemical agents are reported.
1. TB1 administered 50-100mg daily produced an excellent effect.
2. Treatment with INAH was effective upon tuberculoid leprosy. Other types were unchanged or aggravated by this treatment.
3. Toxic manifestations of these drugs were insignificant.
4. The blood concentration of TB1 was recognized after 30 minutes both in the normal and in leprosy patients. It reached the highest after 5 hours in the normal and after 24 hours it was still detected in both cases.
5. The discharged dosis in urine after 24 hours was 27.7% in the normal, and 5.37% in leprosy patients.
6. TB1 was found in a large quantity in the liver, kidney, lung and heart, but not at all in the skin or muscles. The organ concentration was increasing as the administration was continued.
7. The tuberous and macular lesions treated with TB1 did not contain this drug.
8. After the various admintrations of INAH to adult rabbits the variation of blood and organ concentrations was measured.
The results are presented below.
a) After 1 hour the blood concentration presented 13 I/u by subcutaneous injection, 8 I/u by per os admimstration. In every administration mode it decreased to 2 I/cc after 16 hours. The decrease was relatively gradual in subcutaneous injection, prompt after 1 hour in intravenous injection and very slowly in per os administration.
b) After 16 hours subcutaneous injection maintained higher organ concentration than other two methods.
c) By per os administration the concentration war high in the kidney, skin and muscles. As for the periodical variation it increased in the liver and adrenal, and remarkably decreased in the kidney, muscles, brain and lung.
