癩の化学療法に関する研究(第17報)
INAH及びDDSの鼠癩治療実験、特に大量投与試験
1955 年 24 巻 5 号 p. 283-287
詳細
1955 年 24 巻 5 号 p. 283-287
Seven groups of each 20 rats with large lepromata were provided. Groups I, II and III were administered INAH (Hycozid: Takeda) 0.4mg/kg, 4mg/kg, and 40mg/kg, and groups IV, V end VI DDS (Yoshitomi) 1.5mg/kg, 15mg/kg and 150mg/kg, resepectively, six days in a week, per os for 150 days. Group VII was remained untreated as the control.
The size and nature of lepromata was examined at the interval of 30 days, autopsied and the weight of lepromata and bacillus distribution were examined (Tables 1, 2 and 3).
1) In severe murine leprosy 0.4mg/kg of INAH was ineffective for 150 days, but the increased doses of 4.0mg/kg or 40mg/kg was effective. In 4 of 10 cases treated with 40mg/kg INAH for the longest period the lepromatous granulation disappeared, but the bacilli were observed in the site and lymph nodes.
2) DDS was ineffective when administered 1.5mg/kg, 15mg/kg and 150mg/kg, daily.
From these results, the chemical agents appeared most effective when administered by the largest dose as possible.
