STUDIES ON CHEMOTHERAPY OF LEPROSY (Part 18)
ON THE RELATION OF ADMINISTERED DOSES OF INAH AND THE RESISTANCE OF THE MURINE LEPROSY BACILLUS
1955 Volume 24 Issue 6 Pages 402-404
Details
1955 Volume 24 Issue 6 Pages 402-404
The material from the murine leprous rats administered with INAH, 4mg pro kg per os, daily, and total 51mg for 2 months, transplanted into rats. The second leproma was diluted and 0.5cc of the 10-4 suspension was injected into the subcutan of 40 rats. The Group I of 10 rats was administered per os with INAH 4mg pro kg, the Group II with 20mg, the Group III 40mg and the rest Group IV remained as the nontreated control. The results are as shown in Fig. and Table. In the Group I, as well as the control Group, the disease appeared, while, the 20mg and 40mg administration completely prevented the development of the disease. Namely, the bacillus presented the INAH-resistance against 4mg administration, but no resistance more than 20mg administration. This strain, however, produced the disease soon after the discontinuation of the administration, as shown in the Fig.
These above results are available upon the consideration of useful administration of chemical agents and mechanism of the resistance.
