Abstract
The intracutaneous hyaluronidase spreading reaction (H-SR) was examined in the 250 maleand 107 female (L 247, N 82 and M 28) inpatients of Oshima Seishoen.
Generally the H-SR is decreased more remarkably in the patients than in the normal.This tendency is recognized markedly in L type. In N type the function is conservated weland M type is intermediate. In the childhood and adolescence the value is the lowest, gradually increases which is a specific phenomenon in leprosy patients. But the fact that thearea of H-SR is smaller in the male (210.3mm2) than in female (301.1mm2) is similar to thenormal. The acme of erythema nodosum leprosum and the intense of H-SR kept a contraryproportion. At vascular spider manifestation, hyposthesic lesion, leprous macular areas itpresents no difference from the normal skin.
Blood sedimentation rate, autonomic nerve functions, resistance of capillaries and decreaseof acidophile leucocytes has no significance.
To summarize, H-SR in leprosy patients seems to be labil and have multiphases.
