ELECTROPHORETIC SERUM PROTEIN FRACTIONS OF MURINE LEPROSY MICE TREATED WITH INAH AND ITS DERIVATIVES

Abstract

Suppressive and therapeutic studies using INAH and its derivatives were conducted in experimentally infected murine leprosy mice.
Derivatives No. 253, No. 254, No. 282 and No. 284 showed marked suppressive and therapeutic actions. The effect of these agents on the serum protein fractions was examined by paper electrophoresis and the following results obtained.
(1) In the experimentally infected non-treated mice, the albumin is reduced, β-globulin is markedly increased and γ-globulin is almost unchanged compared to the normal control.
(2) The serum protain of the mouse used in the suppressive experiment differs littlefrom that of the normal control. A reduction in albumin and rise in β and γ-globulin was observed in the mice used in the therapeutic experiment but the rise in the β-globulin was smaller compared to that of the untreated animal.
(3) The changes in the serum protein were unrelated to the kind of agent administered.
(4) There was no relationship between the changes in the serum protein of the animals in which medicament had been administered and the numberof murineleprosy bacilli found at the site of inoculation.