抄録
In a previous report, it was shown that the action against murine leprosy of isonicotinoyl-3, 4-dimethoxybenzal hydrazone (No.282) was greater than that of isonicotinoyl-3-methoxy-4-hydroxybenzal hydrazone (No.254). In the present experiment, the action of isonicotinoyl-3-methoxy-4-ethoxyl benzal hydrazone (No.283) and isonicotinoyl-3, 4-diethoxybenzal hydrazone (No.284), in which the methoxy radical has been replaced by the ethoxy radical, against murine leprosy was studied. The toxicity of these two compounds is very low and doses of 4.5g/kg orally are well tolerated by mice. Studies were also conducted on INH, No.254 and No.282 at the same time. It was found that acid-fast bacilli were present after treatment for 3 months with INH, No.254, No.282 and No.283 but could not be found in 3 out of 6 mice given No.284. Leproma formation was detected in the remaining 3 animals but only a small number of acid-fast bacilli could be isolated.
If a reduction or disappearance of acid-fast bacilli should take place when No.284 is administered in mice in which severe leprotic changes are already present, this agent may be useful in the treatment of human leprosy but further study is required.
