1959 Volume 28 Issue 1-2 Pages 43-47
The selection of the mouse strain adequate for murine leprosy experiments has been investigated in the series of previous papers. Through these experiments, it was found that C 57 BL and C 3 H strains were suited for the purpose. Since these two strains can not be easily maintained in a satisfactory condition, the author conducted the following experiments to find the mice which have similar properties to C 57BL and C 3 H and more manageable than these inbred strains in breeding and feeding.
To meet these requirements, the author intended to establish a first generation hybrid (F1) by crossing a male of a susceptible strain with a female of a manageable strain. Therefore, the selection of the parental strains for mating was carried out at first.
The susceptibility to subcutaneous inoculation with murine leprosy bacilli of mouse strains (C 57 BL/6, A 1, NC, dba, BALB/C, SM, C 3 H/He and C 3 H) was examined to select the male parental strain. As a result of this experiment, C 57 BL/6 and C 3 H strins were adequate for the purpose.
As the possible female parental strains, which are easier to breed, ddY and ddD were selected. In susceptibility to murine leprosy bacilli, ddY strain was found to be superior to ddD strain.
