Abstract
The author has dealt with ethis experimental study from the point of view of a foreign body reaction occurring on the host side (guinea-pig) due to insertion of a heterogeneous morbid tissue (human lepromatous nodule). Biological tissue reactions arising then are histologically investigated as fully as possible.
The results of the experiment are as follows:
1. In the beginning non-specific inflammation takes place around the human lepromatous nodule inoculated into the subcutaneous tissue of guinea-pig. Afterwards, a specific granu-lation tissue appears, which is composed from round cell infiltration with leprosy bacilli, including some epithelioid cells.
2. In the neighboring lymph nodes there appears the proliferation of reticulum cells with leprosy bacilli.
3. It is remarked that a difference is recognized between young and adult animals as regards the degree of the initial exudative tissue reaction around the inserted nodule namely higher in the former than in the latter.
4. Regarding necrosis of the inoculated nodule due to the exudative tissue reaction, the change is more severe in adult animals, resulting mostly in abscess formation.
5. Some morphological differences are found between young and adult animals, regarding the specific granulation tissue arising around the inserted nodule: more myxomatous in the former, more solid in the latter.
6. Formation of giant cell begins on the 6th day of the inoculation experiment. Initi-ally, foreign body type is more predominant, then Langhans type and lastly giant cells with very large nuclei are encountered.
