Abstract
The influence upon the immunity caused by the repeated intracutaneous injection of Dharmendra's antigen had been studied experimentally in guinea pigs, and the results obtained were as follows;
1) Fernandez's reaction provoked by Dharmendra's antigen was increased in BCG-vaccinated animals, when the intracutaneous injection of Dharmendra's antigen was tried repeatedly. On the other hand, the influence upon tuberculin reaction was not found either in vaccinated animals or in unvaccinated animals.
2) When the dead BCG-suspension was injected intracutaneously and these injections were repeated instead of Dharmendra's antigen, any influence upon tuberculin reaction and Fernandez's reaction was not found in BCG-vaccinated animals, but both reactions in unvaccinated animals were increased and converted to positive.
3) All experimental animals were challenged by tubercle bacilli for the comparing of the antiinfectious ability against tuberculosis. These abilities were mostly related equivalently to the strength of tuberculin reactions, and were not related to the strength of Fernandez's reaction provoked by Dharmendra's antigen.
