らい性結節性紅斑のビタミンC大量静注療法
1961 年 30 巻 3-4 号 p. 190-192
詳細
1961 年 30 巻 3-4 号 p. 190-192
Regarding the effectiveness of the treatment of ENL (Erythema nodosum leprosum) with Vitamin C (1-ascorbic acid) injection, one of the authors had presented a paper at the 14th Japanese Leprosy Conference in 1940.
The present authors studied again on the same subject with a large dose of the preparation which was administered intravenously with considerable good effects. The results are summarized as follows :
1. The number of leprosy cases with ENL under this treatment amounted to 11 (male 5, female 6).
2. The preparation of Vitamin C employed was Vitacimin (TAKEDA): 1cc. (100mg) and 2cc. (500mg) of 1-ascorbic acid solution in each ampule for intravenous use.
3. The administration of the drug was repeated every day as a daily dose of 100mg, 200mg or 500mg.
4. The total effectivity rate was 73% (8/11).
5. Discolouration of the erythema occurred in 2 to 6 days (4 days on an average), the total amount of ascorbic acid administered being 200 to 3000mg (1328mg on an average).
6. Complete disappearance of the erythema was seen in 4 to 15 days (10 days on an average), the amount of ascorbic acid injected being 660 to 7500mg (3120mg on an average).
7. No side effects were encountered. Furthermore, even in a case with ENL, which brought about mental disorder following cortisone treatment, the Vitamin C therapy was well tolerated and gave a remarkably favorable effect in the treatment of ENL.
