化学療法によるハンセン病の臨床経過と予後の研究

III らい腫型における急性浸潤反応

抄録

This is a report of lepromatous cases with acute infiltration reaction (Tajiri) in his clinical course under chemotherapy. They were all males, among whom one case showed localized skin lesions and other two cases had generalized lesions upon admission. Skin biopsies revealed all borderline-lepromatous features (Ridley-Jopling's classification). This reactions developed one and half to 4 months after the start of treatment, and lasted 9 months to two years intermittently. After this reaction the Mitsuda rection test gave the same result as before in one case, but other two cases became weakly or modelately positive. Bacterial Clearance Time (Takizawa) was 2.7, 4.3 and 5.9 years, respectively.
The nomenclature and the nature of this reaction was discussed, especially with relation to chemotherapy.