ヌードマウスらい症における末梢神経病変

らい菌の侵入経路としての神経周膜

抄録

The main purpose of this report is to describe the electron microscopic findings of peripheral nerve lesions, especially perineural lesion, of experimental nude mouse inoculated with M. leprae isolated from human leproma.
1. Intracytoplasmic foamy structures are observed inside the perineural cells as well as those found inside Schwann cell, axon, macrophage and fibroblast. The intracytoplasmic foamy structures found inside the perineural cells are bigger than those inside the other host cells observed in the peripheral nerve lesions.
2. Invasion route or process of M. leprae into the perineural cells are not elucidated.
3. It is considered that M. leprae inside the phagolysosomes of perineural cell come into the space surrounding perinerum after the rupture of perineural cell by the ending of lifespan.
4. The peripheral nerve lesions of experimental nude mouse inoculated with human M. leprae are not influenced by cell mediated immunity in vivo.
5. Experimental nude mouse inoculated with human M. leprae is a very good model for studying the early stage of histopathological finding of peripheral nerve lesions in lepromatous leprosy