Study of inhibitory mechanism of the chronic inflammation by modification of intestinal metabolism in mice fed several food components

Abstract

　Male C57BL/6J or KK/Ta mice were fed a test diet containing high β -glucan barley, softened Kombu to increase in bioavailability of alginate in Kombu or milk micellar calcium complex (MCP-PP). The mRNA expression of inflammatory markers in epididymal fat cell or pancreas were measured. The mRNA expression of inflammatory markers in epididymal fat was reduced in the both of barley group and softened Kombu group which promote colonic fermentation compared to the control group. On the other hand, the mRNA expressions of IL-1β and If-γ was significantly reduced in the non-fermentable MCP-PP group compared to the control group. These results indicated that the mechanism of anti- inflammatory effect through colonic fermentation by high β -glucan barley and softened Kombu was different from that of MCP-PP.