2014 Volume 65 Issue 1 Pages 12-20
In recent years, Lactobacillales in gut microbiota have been suggested to be in association with obesity. The aim of this study was to investigate a relationship among obesity, serum cholesterol and gut microbiota in Japanese community inhabitants.
Subjects included 613 inhabitants (249 males and 364 females), who participated in the Iwaki Health Promotion Project in 2007. The gut mircoflora extracted from faeces were investigated using terminal restriction fragment length polymorphism (T-RFLP) method and allocated to 28 operational taxonomic units (OTUs). Proportions of OUT332 (Lactobacillales) in gut microbiota were compared among strata of percentages of body fat and serum cholesterol after the subjects were stratified by them. These comparisons were performed in the subjects who were ≥65 years old and <65 years old, respectively.
In women who were ≥65 years old, proportions of OTU332 (Lactobacillales) in the lowest stratum of body fat, serum level of total and LDL cholesterol were the highest in their strata.
A large proportion of Lactobacillales in gut microbiota might reduce absorption of cholesterol, leading to a decrease in body fat of them.
