特集 放射線分科会企画シンポジウム｢放射線の生物・医科学への応用の進展」
CR-39とAFMを用いたマイクロドシメトリ手法の開発とBNCT研究への適用
2005 年 31 巻 1 号 p. 41-48
詳細
2005 年 31 巻 1 号 p. 41-48
In radiation cancer therapies using energetic charged particles such as proton/heavy-ion therapy and boron neutron capture therapy (BNCT), studies on radiation-induced biological response at cellular level is important because the radiation damage from energetic charged particles is highly localized along their paths and the radiation sensitivity is quite different in each cellular organelle. In those studies the information on the position of charged particle impact in biological cells is necessary. We have developed a novel method for high-resolution nuclear track mapping in detailed cellular histology. In this technique, biological specimens mounted on CR-39 plates are exposed to energetic charged particle field. The irradiated samples are exposed to soft X-rays or UV, and then etched for short time. Etch pits for nuclear tracks and relief for transmission X-ray or UV image of the specimen can be observed on the CR-39 surface with an AFM at about 100 nm resolution.
