Abstract
Advanced Trail Making Test (ATMT) is a modified version of Trail Making Test, which has been reported to be useful in discriminating general cognitive decline, but its reliability and validity are unclear. The objectives of this study were first, to examine the reliability and validity of ATMT, and second, to examine the utility of ATMT in discriminating generalized cognitive decline. Retest reliability was low, but validity studies showed that the results of Spearman's correlation analysis revealed that brain function age is an index that comprehensively reflects quickness, energy of brain, and effective utilization, and that quickness is an index of processing speed, energy of brain is an index of selective and sustained attention, and effective utilization is an index of effective utilization. The results of a comparison of the two groups based on the presence or absence of general cognitive decline showed that the group with general cognitive decline was significantly older than the normal group in terms of age and brain age, and that there was a significant decline in quickness, brain vitality, and processing speed. The ROC curves were calculated for the items that showed significant differences, and the highest AUC value was observed for brain age. The cutoff value of brain age was 77.5 years, AUC was 89.8％ , sensitivity was 88.9％ , and specificity was 83.6％ , suggesting that the cutoff value of brain function age measured by ATMT may be useful as a screening for general cognitive decline.
