Association Study between a Novel Single Nucleotide Polymorphism of the Promoter Region of the Prostacyclin Synthase Gene and Essential Hypertension

Tomohiro NAKAYAMA; Masayoshi SOMA; Dolkun RAHMUTULA; Hideko TOBE; Mikano SATO; Jiro UWABO; Noriko AOI; Kotoko KOSUGE; Masako KUNIMOTO; Katsuo KANMATSUSE; Shinichiro KOKUBUN

doi:10.1291/hypres.25.65

Clinical studies

Association Study between a Novel Single Nucleotide Polymorphism of the Promoter Region of the Prostacyclin Synthase Gene and Essential Hypertension

Tomohiro NAKAYAMA, Masayoshi SOMA, Dolkun RAHMUTULA, Hideko TOBE, Mikano SATO, Jiro UWABO, Noriko AOI, Kotoko KOSUGE, Masako KUNIMOTO, Katsuo KANMATSUSE, Shinichiro KOKUBUN

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Keywords: prostacyclin synthase gene, promoter, essential hypertension, single nucleotide polymorphism, association study

JOURNAL FREE ACCESS

2002 Volume 25 Issue 1 Pages 65-68

DOI https://doi.org/10.1291/hypres.25.65

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Abstract

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5′-flanking region. We performed an association study using the SNP in 200 patients and 200 controls. The allele frequency distribution in the two groups was not significantly different. Thus, this SNP in the PGIS gene is not associated with EH. (Hypertens Res 2002; 25: 65-68)

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