Hypertension Research
Online ISSN : 1348-4214
Print ISSN : 0916-9636
ISSN-L : 0916-9636
Association Analyses of RFLPs for the α2- and β1-Adrenoceptor Genes in Essential Hypertension
Robert Y. L. ZeeBrian J. MorrisLyn R. Griffiths
ジャーナル フリー

1992 年 15 巻 1 号 p. 57-60


Adrenoceptor stimulation has an important role in normal cardiovascular regulation and a genetic defect could be a cause of essential hypertension (HT). The present study examined the relationship with HT of RFLPs for the α2-adrenoceptor gene (ADRA2R) and β1-adrenoceptor gene (ADRB1R), which share the same chromosomal locus (10q24-26). Subjects were HTs and normotensives (NTs) whose parents had a similar blood pressure status at age ≥50. The frequency of the minor allele of the DraI RFLP of ADRA2R was 0.17 in HTs (n=76) and 0.17 in NTs (n=87). For the BglI RFLP of ADRBIR, frequency of the minor allele was 0.10 in HTs (n=62) and 0.12 in NTs (n=88). x2 analysis showed no difference between HT and NT groups. Thus the present study provides no basis for involvement of the α2- or β1- adrenoceptor genes in essential hypertension. (Hypertens Res 1992; 15: 57-60)

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