Abstract
It is a contemporary reality the dialectic antagonism between the results of the general human progress (including in the health field, due to which, on one hand, survival ensuring, even in desperate situations, became frequently possible, but also connected to the significant and fast augmenting of the mean life duration: the alert ”demographic ageing” - a population process that generates more elderly, who’s bio-/medico-social characteristic is poli-pathology, with afferent disabilities) and its consequent elevation of the standards/ strivings for individual and/or collective improvements of the peoples’quality of life (QoL) and the - thus - anachronic co-existence of severe disabilities/ handicaps (providing ”veterans of the contemporary medicine”: an unfortunately, actual, inappropriate painful truth and global burden).
The complex modern management of patients with subacute/ subchronic conditions following severe CNS lesions, involves - in addition to neurosurgical intervention(s), if necessary - endeavors for: balanced pharmacological - and not only - stimulation of neuroprotection, neurotrophicity (and even, to some limited extent) of neuro-/synaptogenesis and respectively, modulation of neuroplasticity - all, together and in judicious synergy, with physical-kinesiological (including rehabilitation nursing) speech and/or cognitive-behavioral, therapies.
In this work, I first make an up-to-date general overview on the subject matter, detailing the path-physiological lesional mechanisms consequent to CNS injuries - including intimate targets for neuroprotection - and then, a synthetic presentation of mine and colleagues’ expertise, on neuroprotection, mainly based on four modern related: drugs and respectively, nutritional supplements.
