Extending Dynamic Range and Evaluating Method for Measuring Degree of Red Blood Cell Aggregation with Ultrasonic Peak Frequency

Abstract

A method for monitoring the degree of red blood cell aggregation by using an ultrasonic peak frequency is proposed. To demonstrate the effectiveness of the method, a technique for controlling the degree with a wide dynamic range was necessary. However, efficiently large aggregations could not be generated only by using flocculants for the red blood cells. In this study, we tried to create large aggregations under alkaline conditions, which are known as an aggregation-accelerating factor. We aimed to extend the dynamic range and evaluate the monitoring method.