2023 Volume 21 Issue 1 Pages 62-80
In recent years, the paradigm of clinical understanding of pain and fatigue has shifted to small fiber neuropathy (SFN). SFN is a disorder in which the small fibers (A-delta and C-fibers) of the peripheral nerves are affected. The small fibers are preferentially affected and are responsible for rapid detection and response to threats in the external and internal environment. Persistent SFN causes chronic pain due to sensory neuropathy and pathological fatigue, and multiple organ damage due to autonomic neuropathy. Idiopathic SFNs (iSFNs), which account for approximately 50% of SFNs, are caused by homeostatic distortion. Effective therapeutic intervention at the initial iSFN (iiSFN) stage can not only prevent the onset of chronic disabling bodily distress (CDBD), which is intractable chronic pain and chronic fatigue, but also lead to recovery of health and disease prevention.
