International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
Clinical Studies
Angiographic and Clinical Outcome Following Sirolimus-Eluting Stent (Cypher) Implantation
A Single Center Experience
Turkay OzcanV. Gokhan CinMustafa YurtdasBurak AkcaySabri SeyisArmagan AceleDilek CicekAhmet CamsariNecdet AkkusOben Doven
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Volume 48 (2007) Issue 1 Pages 11-23

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Abstract

Objectives:
To investigate the late outcomes of sirolimus-eluting stent implantation in patients with coronary artery disease.
Background:
Drug-eluting stents reduce intimal hyperplasia, which is the main cause of in-stent restenosis. Sirolimus-eluting stents significantly reduce clinical and angiographic restenosis and improve event-free survival.
Methods:
The study population consisted of 207 patients (273 stents) who had undergone coronary Cypher stent implantation. Patients were eligible for enrollment if there was symptomatic coronary artery disease or positive exercise testing, and angiographic evidence of single or multivessel disease with a target lesion stenosis of ≥ 70% in a ≥ 2.25 mm vessel. Follow-up coronary angiography was performed 18 months after stent deployment. Patients were followed-up for a mean of 24.7 ± 7.4 months.
Results:
All patients survived after stent implantation, but 5 (2.4%) patients experienced acute ST elevation myocardial infarction and 4 (1.9%) patients developed non-Q wave myocardial infarction following angioplasty. Recurrent angina pectoris was observed in 16 (7.7%) patients (11 stable angina pectoris and 5 unstable angina pectoris). Angiographic evidence of restenosis was observed in these 20 (9.66%) patients. The 5 other patients had noncritical angiographic restenosis. Eleven (5.3%) patients underwent angioplasty because of restenosis, and coronary artery bypass grafting was conducted in the other 9 (4.3%) patients.
Conclusion:
The results of the present study indicate that Cypher stents could be implanted with a very high success rate and have encouraging long-term angiographic and clinical results.

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© 2007 by the International Heart Journal Association
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