International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
Clinical Studies
Clarifying the Arrhythmogenic Substrate for Brugada Syndrome
Electroanatomic Mapping Study of the Right Ventricle
Masayoshi KofuneIchiro WatanabeKimie OhkuboSonoko AshinoYasuo OkumuraKoichi NagashimaHiroaki ManoToshiko NakaiYuji KasamakiAtsushi Hirayama
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2011 Volume 52 Issue 5 Pages 290-294


The right ventricular outflow tract (RVOT) is considered the arrhythmogenic region that gives rise to Brugada syndrome. To obtain a better understanding of this substrate, we performed electroanatomic mapping of the right ventricle (RV) in patients with Brugada syndrome.
The RV was mapped electroanatomically with the CARTO system in 11 patients with asymptomatic Brugada syndrome but in whom ventricular fibrillation was induced by programmed ventricular stimulation, and in 5 control patients. The low voltage zone area (< 1.5 mV) was larger (16.1% versus 7.8%, P < 0.01) and the bipolar electrogram duration was greater (81.6 ± 7.8 ms versus 53.4 ± 5.6 ms, P < 0.01) in the patients with Brugada syndrome versus the control patients; the bipolar electrogram duration was greater in the septal portion and free wall of the RVOT.
Our data suggest that regional endocardial conduction slowing based on structural abnormalities exists at the RVOT in Brugada syndrome.

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© 2011 by the International Heart Journal Association
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