Myocardial Involvement in Patients With Osteogenesis Imperfecta

Katsura Soma; Hajime Abe; Norihiko Takeda; Yukako Shintani; Yutaka Takazawa; Toshiya Kojima; Katsuhito Fujiu; Hiroaki Semba; Hiroshi Yamashita; Yasunobu Hirata; Masashi Fukayama; Ryozo Nagai

doi:10.1536/ihj.53.75

Case Reports

Myocardial Involvement in Patients With Osteogenesis Imperfecta

Katsura Soma, Hajime Abe, Norihiko Takeda, Yukako Shintani, Yutaka Takazawa, Toshiya Kojima, Katsuhito Fujiu, Hiroaki Semba, Hiroshi Yamashita, Yasunobu Hirata, Masashi Fukayama, Ryozo Nagai

著者情報

キーワード: Osteogenesis imperfecta, Type 1 collagen, Mitral valve regurgitation, Myocardial fibrosis

ジャーナルフリー

2012 年 53 巻 1 号 p. 75-77

DOI https://doi.org/10.1536/ihj.53.75

詳細

抄録

Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）