International Heart Journal
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
Clinical Studies
Comparison of Efficacy and Safety of Azilsartan and Olmesartan in Patients With Essential Hypertension
A Randomized and Prospective Study (CANZONE Study)
Yuhei ShigaShin-ichiro MiuraKota MotozatoKenji NorimatsuMasaya YanoYuka HitakaSen AdachiTakashi KuwanoKen InoueAsao InoueKazuaki FujisawaTetsuro ShirotaniTakaaki KusumotoMunehito IdeishiKeijiro Saku
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2017 Volume 58 Issue 3 Pages 416-421

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Abstract

Many patients still have high blood pressure (BP) after treatment with angiotensin II type 1 (AT1) receptor blockers (ARBs). We compared the efficacy and safety of azilsartan to those of olmesartan in a prospective randomized clinical trial. Sixty-four hypertensive patients who were treated with ARBs other than azilsartan and olmesartan were enrolled in this study. We randomly assigned patients to changeover from their prior ARBs to either azilsartan or olmesartan, and followed the patients for 3 months. Systolic BP (SBP) in the azilsartan group was significantly decreased at 3 months, and diastolic BP (DBP) and pulse rate (PR) in the olmesartan group showed significant reductions after 3 months. There were no significant differences in ΔSBP, ΔDBP, or ΔPR (Δ = the value at 3 months minus the value at 0 months) between the groups. Serum levels of creatinine (Cr), uric acid (UA), and potassium (K) in the azilsartan group significantly increased after 3 months. While the changes in Cr, UA, and K were within the respective normal ranges, ΔSBP was positively associated with ΔCr in the azilsartan group. In conclusion, there was no difference in the depressor effects of azilsartan and olmesartan, and there were no serious changes in biochemical parameters with azilsartan and olmesartan.

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© 2017 by the International Heart Journal Association
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