Ponatinib-Related Vasospastic Angina

Michiho Shindo; Chinatsu Komiyama; Tetsuo Yamaguchi; Kosei Kageyama; Hisashi Yamamoto; Yo Fujimoto; Naoyuki Uchida; Takahide Kodama

doi:10.1536/ihj.23-355

Case Reports

Ponatinib-Related Vasospastic Angina

Michiho Shindo, Chinatsu Komiyama, Tetsuo Yamaguchi, Kosei Kageyama, Hisashi Yamamoto, Yo Fujimoto, Naoyuki Uchida, Takahide Kodama

Author information

Keywords: Tyrosine kinase inhibitor, Vasospasm, Chronic myeloid leukemia, Onco-cardiology, Cardio-oncology

JOURNAL FREE ACCESS

2024 Volume 65 Issue 2 Pages 349-353

DOI https://doi.org/10.1536/ihj.23-355

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Abstract

Tyrosine kinase inhibitors (TKIs) are essential drugs for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Cardiovascular or arteriothrombotic adverse events have been reported in patients treated with TKIs. We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.

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