A Successful Spontaneous Delivery Case after Cardioprotective Drug Discontinuation for Severe Doxorubicin-Induced Cardiomyopathy

A Case Report

Abstract

Evidence for pregnancy in patients with drug-induced cardiomyopathy is limited, presenting significant challenges in medication management for such cases.

A 28-year-old female patient developed severe heart failure due to doxorubicin-induced cardiomyopathy following treatment for extraosseous Ewing's sarcoma. After a decade of heart failure management, the patient successfully achieved a safe pregnancy and delivery.

This report describes how we reduced and discontinued cardioprotective drugs for heart failure and prompted an evaluation of her ability to tolerate an increased circulating plasma volume through a saline stress test, followed by infertility treatment.