Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis A Case Report

Wenjun Wang; Bailu Wang; Yuguo Chen; Shujian Wei

doi:10.1536/ihj.20-309

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Late Stent Thrombosis After Drug-Coated Balloon Coronary Angioplasty for In-Stent Restenosis

A Case Report

Wenjun Wang, Bailu Wang, Yuguo Chen, Shujian Wei

著者情報

Wenjun Wang
Department of Emergency and Chest Pain Center, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Cheeloo College of Medicine, Qilu Hospital of Shandong University
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Bailu Wang
Clinical Trial Center, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Yuguo Chen
Department of Emergency and Chest Pain Center, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Cheeloo College of Medicine, Qilu Hospital of Shandong University
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Shujian Wei
Department of Emergency and Chest Pain Center, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Clinical Research Center for Emergency and Critical Care Medicine of Shandong Province, Institute of Emergency and Critical Care Medicine of Shandong University, Cheeloo College of Medicine, Qilu Hospital of Shandong University
Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Cheeloo College of Medicine, Qilu Hospital of Shandong University
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Cheeloo College of Medicine, Qilu Hospital of Shandong University

キーワード: Coronary artery disease, Gene mutation, Antiplatelet strategy, Myocardial infarction

ジャーナルフリー早期公開

論文ID: 20-309

DOI https://doi.org/10.1536/ihj.20-309

この記事には本公開記事があります。

The final version of this article is now available: Vol. 62 (2021), No. 1 pp. 171-174

詳細

抄録

A 41-year-old woman with chest pain for 6 hours was admitted to our chest pain center, presenting with acute myocardial infarction. Coronary angiography showed acute total occlusion in the proximal left anterior descending artery due to late stent thrombosis. After thrombus aspiration and intracoronary administration of 0.5 mg tirofiban, repeated angiography showed that no obvious residual stenosis remained. The patient underwent drug-coated balloon angioplasty 69 days ago and was then administered dual antiplatelet treatment (aspirin and clopidogrel) uninterruptedly. Genetic testing found that both cytochrome P450 2C19 (CYP2C19) (G681A) and glycoprotein Ia (GPIa) (C807T, G873A) were hybrid mutant types, demonstrating that the patient was possibly resistant to clopidogrel and aspirin simultaneously. Thus, clopidogrel was replaced by ticagrelor and no more cardiovascular adverse events occurred during the 2-year follow-up.

責任著者(Corresponding author)

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