The Uric Acid to High-Density Lipoprotein Cholesterol Ratio Is Associated with Left Ventricular Diastolic Function in Patients with No Significant Perfusion Abnormality

Assessment by Myocardial Perfusion Single-Photon Emission Computed Tomography

Abstract

The ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) is a marker of inflammation. However, whether this ratio is associated with left ventricular (LV) diastolic function remains unknown. This study tested the hypothesis that the UA-to-HDL-C ratio is associated with LV diastolic parameters derived from gated myocardial perfusion single-photon emission computed tomography (SPECT) in patients with no significant perfusion abnormalities.

The study population included 204 patients with no significant perfusion abnormalities and a preserved ejection fraction. The peak filling rate (PFR) and one-third mean filling rate (1/3 MFR) were obtained as LV diastolic parameters using gated SPECT. Serum UA and plasma HDL-C levels were also examined.

Significant associations were observed between the UA-to-HDL-C ratio and the PFR (r = −0.20; P = 0.005) and 1/3 MFR (r = −0.17; P = 0.018). Multivariate linear regression analysis was performed to determine the factors associated with LV diastolic parameters. Age (β = −0.13; P = 0.046), the LV end-diastolic volume (β = −0.17; P = 0.046), and the UA-to-HDL-C ratio (β = −0.17; P = 0.023) were significantly associated with the PFR. Moreover, age (β = −0.18; P = 0.011), the LV mass index (β = −0.19; P = 0.011), and the UA-to-HDL-C ratio (β = −0.14; P = 0.047) were significantly associated with the 1/3 MFR.

These results demonstrated that the UA-to-HDL-C ratio is associated with LV diastolic function derived from gated SPECT in patients with no significant perfusion abnormalities.